Migraine Headaches in Women
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چکیده
The neurovascular theory does is contrary to the vascular theory and instead suggest the vasodilation is a phenomenon that is a associated with trigeminal nerve axon activation from triggering mechanisms. This then releases neuropeptides such as substance P, neurokinin A, and CGRP (a potent vasodilator) from axon terminals near the meningeal and other blood vessels. This then produces an inflammatory response in the area around the innervated blood vessels. These neuropeptides also sensitize nerve endings which is a perpetuating factor in prolonging the headache.
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